McDonald's 338 2nd Street Pike, Southampton, PA18966 McDonald's is located on Second Street Pike in Southampton. It features a play area for kids, ample parking and outdoor…More seating. It is perfect for those on a budget and looking for a great meal. McDonald's is also open early for that quick stop on the way to work for premium roast coffee and other breakfast items. They are available seven days a week, offer free wifi and accept major credit cards.